The drug's physicochemical and biological properties, such as stability, volatility, solubility, and dispersibility, will alter as it forms an inclusion complex with cyclodextrin. The following characteristics reflect the particular benefits:
(1) Increased solubility: Making pharmaceutical preparations is made easier when a drug's solubility is increased.
(2) Increased stability: When a medicine forms an inclusion complex, the active group is shielded, limiting the amount of time it is subjected to oxidation, heat, light, or other chemical conditions before it degrades and becomes less stable.
(3) Powdering liquid medications (such volatile oils) helps stop the vaporization of volatile ingredients. For some liquid medications, cyclodextrin inclusion can cause the medication to solidify, which makes it easier to prepare and use preparations.
(4) Cover up the unpleasant flavor or odor of the medication: For some drugs with unpleasant odors, the odor can be covered up after inclusion to improve patient compliance.
(5) Improve the absorption of drugs and improve the bioavailability of drugs: cyclodextrin itself can be used as a penetration enhancer to improve the absorption of topical administration, and increase the administration methods such as transdermal administration, mucosal administration, and ocular administration. The amount of drug permeation can be improved, thereby improving drug absorption and increasing drug bioavailability. At the same time, for some active substances that have been eliminated due to their low bioavailability, the inclusion of cyclodextrin has the possibility of being re-developed into drugs.
(6) Lessen the drug's irritant and poisonous side effects: On the one hand, the inclusion compound lowers the dosage, and on the other, it can lower the concentration of the free drug. As a result, the drug's toxic and side effects are significantly lessened.
(7) Cyclodextrin inclusion has a delayed medication release and little side effects, similar to microcapsules.
The medicine can also be converted into different dosage forms, such as granules, capsules, pills, injections, and the like, after it has been transformed into the cyclodextrin inclusion component, which is a preparation procedure rather than a preparation.